Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity

• Main Authors: Huang, Zhenxing, Wang, Jianhe, Xu, Xiaoli, Wang, Haishan, Qiao, Yuan, Chu, Wern Cui, Xu, Shengli, Chai, Louis, Cottier, Fabien, Pavelka, Norman, Oosting, Marije, Joosten, Leo A. B., Netea, Mihai, Ng, Carol Yee Leng, Leong, Khai Pang, Kundu, Parag, Lam, Kong-Peng, Pettersson, Sven, Wang, Yue
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Antimicrobial Responses; Autoimmune Diseases
• Online Access: https://hdl.handle.net/10356/147107
• Institution: Nanyang Technological University

The human microbiota provides tonic signals that calibrate the host immune response1,2, but their identity is unknown. Bacterial peptidoglycan (PGN) subunits are likely candidates since they are well-known immunity-enhancing adjuvants, released by most bacteria during growth, and have been found in...