Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease

• Main Authors: Radulescu, Carola I., Garcia-Miralles, Marta, Sidik, Harwin, Bardile, Costanza Ferrari, Nur Amirah Mohammad Yusof, Lee, Hae Ung, Ho, Eliza Xin Pei, Chu, Collins Wenhan, Layton, Emma, Low, Donovan, De Sessions, Paola Florez, Pettersson, Sven, Ginhoux, Florent, Pouladi, Mahmoud A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Huntington Disease; White Matter
• Online Access: https://hdl.handle.net/10356/148697
• Institution: Nanyang Technological University

Structural and molecular myelination deficits represent early pathological features of Huntington disease (HD). Recent evidence from germ-free (GF) animals suggests a role for microbiota-gut-brain bidirectional communication in the regulation of myelination. In this study, we aimed to investigate th...