Toward a single-dose cure for buruli ulcer
A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may dramatically simplify the clinical management of Buruli ulcer, a negle...
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sg-ntu-dr.10356-1489272023-03-05T16:28:46Z Toward a single-dose cure for buruli ulcer Thomas, Sangeeta Susan Kalia, Nitin Pal Ruf, Marie-Thérèse Pluschke, Gerd Pethe, Kevin Interdisciplinary Graduate School (IGS) Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Science::Medicine Mycobacterium Ulcerans Tuberculosis A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may dramatically simplify the clinical management of Buruli ulcer, a neglected mycobacterial disease. Nanyang Technological University National Medical Research Council (NMRC) National Research Foundation (NRF) Published version This work was supported in part by the Singapore Ministry of Health’s National Medical Research Council under its Cooperative Basic Research Grant (project award NMRC/CBRG/0083/2015), the Lee Kong Chian School of Medicine, Nanyang Technological University Start-Up Grant (K.P.), and the National Research Foundation Competitive Research Program (CRP) grant award number NRF–CRP18–2017–01. N.P.K. is a Ramalingaswami Fellow, Clinical Microbiology Division, CSIR-IIIM, Jammu and Kashmir, India. S.S.T. was supported by an Interdisciplinary Graduate School Scholarship from the Nanyang Technological University. We thank Michael Berney for critical reading of the manuscript. 2021-05-18T04:57:25Z 2021-05-18T04:57:25Z 2020 Journal Article Thomas, S. S., Kalia, N. P., Ruf, M., Pluschke, G. & Pethe, K. (2020). Toward a single-dose cure for buruli ulcer. Antimicrobial Agents and Chemotherapy, 64(9). https://dx.doi.org/10.1128/AAC.00727-20 0066-4804 https://hdl.handle.net/10356/148927 10.1128/AAC.00727-20 32631818 2-s2.0-85089787843 9 64 en NMRC/CBRG/0083/2015 NRF–CRP18–2017–01 Antimicrobial Agents and Chemotherapy © 2020 American Society for Microbiology (ASM). All rights reserved. This paper was published in Antimicrobial Agents and Chemotherapy and is made available with permission of American Society for Microbiology (ASM). application/pdf |
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Science::Medicine Mycobacterium Ulcerans Tuberculosis |
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Science::Medicine Mycobacterium Ulcerans Tuberculosis Thomas, Sangeeta Susan Kalia, Nitin Pal Ruf, Marie-Thérèse Pluschke, Gerd Pethe, Kevin Toward a single-dose cure for buruli ulcer |
| description |
A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may dramatically simplify the clinical management of Buruli ulcer, a neglected mycobacterial disease. |
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Interdisciplinary Graduate School (IGS) |
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Interdisciplinary Graduate School (IGS) Thomas, Sangeeta Susan Kalia, Nitin Pal Ruf, Marie-Thérèse Pluschke, Gerd Pethe, Kevin |
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Article |
| author |
Thomas, Sangeeta Susan Kalia, Nitin Pal Ruf, Marie-Thérèse Pluschke, Gerd Pethe, Kevin |
| author_sort |
Thomas, Sangeeta Susan |
| title |
Toward a single-dose cure for buruli ulcer |
| title_short |
Toward a single-dose cure for buruli ulcer |
| title_full |
Toward a single-dose cure for buruli ulcer |
| title_fullStr |
Toward a single-dose cure for buruli ulcer |
| title_full_unstemmed |
Toward a single-dose cure for buruli ulcer |
| title_sort |
toward a single-dose cure for buruli ulcer |
| publishDate |
2021 |
| url |
https://hdl.handle.net/10356/148927 |
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1759854653265149952 |