Toward a single-dose cure for buruli ulcer

• Main Authors: Thomas, Sangeeta Susan, Kalia, Nitin Pal, Ruf, Marie-Thérèse, Pluschke, Gerd, Pethe, Kevin
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Mycobacterium Ulcerans; Tuberculosis
• Online Access: https://hdl.handle.net/10356/148927
• Institution: Nanyang Technological University

A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may dramatically simplify the clinical management of Buruli ulcer, a negle...