Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity

• Main Authors: Ngo, Khac Huy, Yang, Renliang, Das, Poulomi, Nguyen, Giang Kien Truc, Lim, Kah Wai, Tam, James P., Wu, Bin, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry::Biochemistry; Science::Biological sciences; Guanine Quadruplex; Membrane Protein
• Online Access: https://hdl.handle.net/10356/150540
• Institution: Nanyang Technological University

G-quadruplexes(G4) arenon-canonical nucleicacidstructures with important implications in biology. Based on an a-helical fragment of the RHAU helicase that displays high specificity for parallelstranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase. The c...