Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity

Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity

G-quadruplexes(G4) arenon-canonical nucleicacidstructures with important implications in biology. Based on an a-helical fragment of the RHAU helicase that displays high specificity for parallelstranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-eﬃciency ligase. The c...

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書目詳細資料
Main Authors:	Ngo, Khac Huy, Yang, Renliang, Das, Poulomi, Nguyen, Giang Kien Truc, Lim, Kah Wai, Tam, James P., Wu, Bin, Phan, Anh Tuân
其他作者:	School of Physical and Mathematical Sciences
格式:	Article
語言:	English
出版:	2022
主題:	Science::Chemistry::Biochemistry Science::Biological sciences Guanine Quadruplex Membrane Protein
在線閱讀:	https://hdl.handle.net/10356/150540
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!
機構:	Nanyang Technological University
語言:	English

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