Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity

• المؤلفون الرئيسيون: Ngo, Khac Huy, Yang, Renliang, Das, Poulomi, Nguyen, Giang Kien Truc, Lim, Kah Wai, Tam, James P., Wu, Bin, Phan, Anh Tuân
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry::Biochemistry; Science::Biological sciences; Guanine Quadruplex; Membrane Protein
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/150540

G-quadruplexes(G4) arenon-canonical nucleicacidstructures with important implications in biology. Based on an a-helical fragment of the RHAU helicase that displays high specificity for parallelstranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase. The c...