Guanidine-copper complex catalyzed allylic borylation for the enantioconvergent synthesis of tertiary cyclic allylboronates

• Main Authors: Ge, Yicen, Cui, Xi-Yang, Tan, Siu Min, Jiang, Huan, Ren, Jingyun, Lee, Nicholas, Lee, Richmond, Tan, Choon-Hong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Asymmetric Catalysis; Borylation
• Online Access: https://hdl.handle.net/10356/151801
• Institution: Nanyang Technological University

An enantioconvergent synthesis of chiral cyclic allylboronates from racemic allylic bromides was achieved by using a guanidine-copper catalyst. The allylboronates were obtained with high γ/α regioselectivities (up to 99:1) and enantioselectivities (up to 99 % ee), and could be further transformed in...