Cell-free DNA promotes thrombin autolysis and generation of thrombin-derived C-terminal fragments

• Main Authors: Saravanan, Rathi, Choong, Yeu Khai, Lim, Chun Hwee, Lim, Li Ming, Petrlova, Jitka, Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Thrombin; Host Defense Peptides
• Online Access: https://hdl.handle.net/10356/152056
• Institution: Nanyang Technological University

Cell-free DNA (cfDNA) is the major structural component of neutrophil extracellular traps (NETs), an innate immune response to infection. Antimicrobial proteins and peptides bound to cfDNA play a critical role in the bactericidal property of NETs. Recent studies have shown that NETs have procoagulan...