Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners

• Main Authors: Molton, James S., Lee, I. Russel, Bertrand, Denis, Ding, Ying, Kalimuddin, Shirin, Lye, David C., Nagarajan, Niranjan, Gan, Yunn-Hwen, Archuleta, Sophia
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Klebsiella Pneumoniae; Liver Abscess
• Online Access: https://hdl.handle.net/10356/153866
• Institution: Nanyang Technological University

Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.