C2 amination of pyridine with primary amines mediated by sodium hydride in the presence of lithium iodide

N-Butylpyridin-2-amine (3). An oven-dried, 250 mL three-necked roundbottomed flask fitted with a 25 x 15 mm Teflon-coated oval magnetic stir bar, a thermometer, rubber septum and a Liebig reflux condenser, is connected to a Schlenk line (Note 2). Sodium hydride (NaH) (3.00 g, 75.0 mmol, 3.0 equiv)...

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Bibliographic Details
Main Authors: Pang, Jia Hao, Ong, Derek Yiren, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/154826
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Institution: Nanyang Technological University
Language: English