Carbene-catalyzed activation of formyl-phenylacetic esters for access to chiral dihydroisoquinolinones

• Main Authors: Wu, Shuquan, Xu, Jun, Deng, Rui, Wang, Hongling, Chi, Robin Yonggui, Zheng, Pengcheng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Substituents; Chemical Reactions
• Online Access: https://hdl.handle.net/10356/155070
• Institution: Nanyang Technological University

A carbene-catalyzed reaction to synthesize chiral dihydroisoquinolinones via an o-quinodimethane (o-QDM) intermediate is disclosed. o-QDM reacts with cyclic sulfonic imines via annulation to afford highly enantioenriched dihydroisoquinolinone products. ESI-HRMS studies suggest a stepwise Mannich add...