MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites

• المؤلفون الرئيسيون: See, Yi Xiang, Chen, Kaijing, Fullwood, Melissa Jane
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences::Genetics; Science::Biological sciences::Molecular biology; Chromatin Interactions; Cancer
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155129

The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Since...