Mycobacterium tuberculosis PanD structure-function analysis and identification of a potent pyrazinoic acid-derived enzyme inhibitor

• Main Authors: Ragunathan, Priya, Cole, Malcolm, Latka, Chitra, Aragaw, Wassihun Wedajo, Hegde, Pooja, Shin, Joon, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Aldrich, Courtney C., Dick, Thomas, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biochemistry; Science::Chemistry::Analytical chemistry; Tuberculosis; Mycobacteria; Pyrazinamide; Pyrazinoic Acid; Coenzyme A; Aspartate Decarboxylase
• Online Access: https://hdl.handle.net/10356/155645
• Institution: Nanyang Technological University

A common strategy employed in antibacterial drug discovery is targeting of biosynthetic processes which are essential and specific for the pathogen. Specificity in particular avoids undesirable interactions with potential enzymatic counterparts in the human host, and ensures on-target toxicity. S...