A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides

A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides

Joining peptides and oligonucleotides offers potential benefits, but current methods remain laborious. Here we present a novel approach towards enzymatic ligation of the two modalities through the development of tag phosphoramidites that readily couple onto oligonucleotides. This simple and highly e...

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Bibliographic Details
Main Authors: Tan, Derrick Jing Yang, Cheong, Vee Vee, Lim, Kah Wai, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Science::Chemistry
Peptides
Oligonucleotides
Online Access:https://hdl.handle.net/10356/158325
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Institution: Nanyang Technological University
Language: English
Description
Summary:Joining peptides and oligonucleotides offers potential benefits, but current methods remain laborious. Here we present a novel approach towards enzymatic ligation of the two modalities through the development of tag phosphoramidites that readily couple onto oligonucleotides. This simple and highly efficient approach paves the way towards streamlined development and production of peptide/protein-oligonucleotide conjugates.

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