A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides

• المؤلفون الرئيسيون: Tan, Derrick Jing Yang, Cheong, Vee Vee, Lim, Kah Wai, Phan, Anh Tuân
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Science::Chemistry; Peptides; Oligonucleotides
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/158325

Joining peptides and oligonucleotides offers potential benefits, but current methods remain laborious. Here we present a novel approach towards enzymatic ligation of the two modalities through the development of tag phosphoramidites that readily couple onto oligonucleotides. This simple and highly e...