Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

• Main Authors: Kinnebrew, Maia, Luchetti, Giovanni, Sircar, Ria, Frigui, Sara, Viti, Lucrezia Vittoria, Naito, Tomoki, Beckert, Francis, Saheki, Yasunori, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Cell Membrane; Cholesterol
• Online Access: https://hdl.handle.net/10356/160768
• Institution: Nanyang Technological University

A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al., 2019) that PTCH1 inhibits Smoothened by depl...