A flexi-PEGDA upconversion implant for wireless brain photodynamic therapy

• Main Authors: Teh, Daniel Boon Loong, Bansal, Akshaya, Chai, Chou, Toh, Tan Boon, Tucker, Robert Alan Jappy, Gammad, Gil Gerald Lasam, Yeo, Yanzhuang, Lei, Zhendong, Zheng, Xiang, Yang, Fengyuan, Ho, John S., Bolem, Nagarjun, Wu, Bing Cheng, Gnanasammandhan, Muthu Kumar, Hooi, Lissa, Dawe, Gavin Stewart, Libedinsky, Camilo, Ong, Wei-Yi, Halliwell, Barry, Chow, Edward Kai-Hua, Lim, Kah-Leong, Zhang, Yong, Kennedy, Brian K.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Hydrogels; Optical Fibers
• Online Access: https://hdl.handle.net/10356/161089
• Institution: Nanyang Technological University

Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unseque...