Data-driven analysis of COVID-19 reveals persistent immune abnormalities in convalescent severe individuals

• Main Authors: Lim, Jackwee, Puan, Kia Joo, Wang, Liang Wei, Teng, Karen Wei Weng, Loh, Chiew Yee, Tan, Kim Peng, Carissimo, Guillaume, Chan, Yi-Hao, Poh, Chek Meng, Lee, Cheryl Yi-Pin, Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chee, Rhonda Sin-Ling, Siti Naqiah Amrun, Chang, Zi Wei, Tay, Matthew Zirui, Torres-Ruesta, Anthony, Leo Fernandez, Norman, How, Wilson, Andiappan, Anand Kumar, Lee, Wendy, Duan, Kaibo, Tan, Seow-Yen, Yan, Gabriel, Kalimuddin, Shirin, Lye, David Chien, Leo, Yee Sin, Ong, Sean Wei Xiang, Young, Barnaby Edward, Renia, Laurent, Ng, Lisa F. P., Lee, Bernett, Rötzschke, Olaf
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; COVID-19; Cytokine Profile
• Online Access: https://hdl.handle.net/10356/161473
• Institution: Nanyang Technological University

Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains uncle...