Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells

• Main Authors: Su, Liping, Kong, Xiaocen, Loo, Szejie, Gao, Yu, Liu, Bingli, Su, Xiaofei, Dalan, Rinkoo, Ma, Jianhua, Ye, Lei
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Endothelium; Senescence
• Online Access: https://hdl.handle.net/10356/163078
• Institution: Nanyang Technological University

Background: Prior studies show that signature phenotypes of diabetic human induced pluripotent stem cells derived endothelial cells (dia-hiPSC-ECs) are disrupted glycine homeostasis, increased senescence, impaired mitochondrial function and angiogenic potential as compared with healthy hiPSC-ECs. In...