Selective one-pot cascade synthesis of N-substituted highly functionalized pyrroles from unprotected sugars, primary amines, and oxoacetonitriles

• Main Authors: Xia, Mengxin, Lambu, Mallikharjuna Rao, Judeh, Zaher M. A.
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Engineering::Chemical engineering; Cascade Reactions; Embeddings
• 在線閱讀: https://hdl.handle.net/10356/163328
• 機構: Nanyang Technological University

A one-pot, three-component cascade reaction between unprotected sugars, primary amines, and 3-oxoacetonitriles gave N-substituted 2,3,5-functionalized pyrroles or N-substituted 2,3,4-functionalized pyrroles in excellent yields and selectivities. The selectivity of the reaction was achieved by simple...