CRISPR/Cas9-induced DNA damage enriches for mutations in a p53-linked interactome: implications for CRISPR-based therapies

Inactivating p53 mutations are the most abundant genetic alterations found in cancer. Here we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient in p53 and in genes of a core CRISPR-p53 tumor suppressor interactome. Such enrichment could predispose to cancer developm...

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Bibliographic Details
Main Authors: Jiang, Long, Ingelshed, Katrine, Shen, Yunbing, Boddul, Sanjaykumar V., Iyer, Vaishnavi Srinivasan, Kasza, Zsolt, Sedimbi, Saikiran, Lane, David P., Wermeling, Fredrik
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/163561
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Institution: Nanyang Technological University
Language: English

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