Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion

• Main Authors: Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Adenosine Triphosphate; Diabetes Mellitus
• Online Access: https://hdl.handle.net/10356/163808
• Institution: Nanyang Technological University

Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic β-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-se...