Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea

• Main Authors: Gu, Xiaoqiong, Sim, Jean X. Y., Lee, Wei Lin, Cui, Liang, Chan, Yvonne F. Z., Chang, Ega Danu, Teh, Yii Ean, Zhang, An-Ni, Armas, Federica, Chandra, Franciscus, Chen, Hongjie, Zhao, Shijie, Lee, Zhanyi, Thompson, Janelle, Ooi, Eng Eong, Low, Jenny G., Alm, Eric J., Kalimuddin, Shirin
• Other Authors: Asian School of the Environment
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Microbiome; Pathophysiology
• Online Access: https://hdl.handle.net/10356/164207
• Institution: Nanyang Technological University

Antibiotic-associated diarrhea (AAD) affects a significant proportion of patients receiving antibiotics. We sought to understand if differences in the gut microbiome would influence the development of AAD. We administered a 3-day course of amoxicillin-clavulanate to 30 healthy adult volunteers, and...