Expanding the scope of substrate specificity for peptide asparaginyl ligases

Asparaginyl endopeptidases (AEPs) are Asn/Asp (Asx)-specific proteases. Peptide asparaginyl ligases (PALs) belong to AEPs that exhibit dominant ligase activity, making them valuable stand-alone biotechnological and biochemical tools for precision biomanufacturing of proteins. Structure-guided mut...

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Bibliographic Details
Main Author: Lim, Ching Koon
Other Authors: James P Tam
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/165142
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Institution: Nanyang Technological University
Language: English