Expanding the ligation toolbox through protein engineering of peptide asparaginyl ligases (PALs)

Asparaginyl endopeptidases (AEPs) are thiol proteases that cleave peptide bonds after Asn/Asp(Asx) residues. However, certain AEPs also make Asx bonds and which we named peptide asparaginyl ligases (PALs). PALs, ATP-independent and stand-alone, are ideal for site-specific modifications of proteins,...

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Bibliographic Details
Main Author: Tan, Shaun Jun Hao
Other Authors: James P Tam
Format: Thesis-Master by Research
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/169289
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Institution: Nanyang Technological University
Language: English