Expanding the scope of substrate specificity for peptide asparaginyl ligases

• المؤلف الرئيسي: Lim, Ching Koon
• مؤلفون آخرون: James P Tam
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2023
• الموضوعات: Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/165142

Asparaginyl endopeptidases (AEPs) are Asn/Asp (Asx)-specific proteases. Peptide asparaginyl ligases (PALs) belong to AEPs that exhibit dominant ligase activity, making them valuable stand-alone biotechnological and biochemical tools for precision biomanufacturing of proteins. Structure-guided mut...