Expanding the substrate specificity of peptide asparaginyl ligase

• المؤلف الرئيسي: Chua, Niying
• مؤلفون آخرون: Julien Lescar
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2023
• الموضوعات: Science::Biological sciences::Evolution; Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/168598

Through amide bond formation, peptide ligases (such as sortase A and subtiligase) introduce specific protein modifications, providing a specific and affordable tool for protein conjugation. Although sortases and subtiligases are capable of site-specific protein conjugations, their slow ligation rea...