Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI

• Main Authors: Mathiyazakan, Vikneswaran, Wong, Chui Fann, Harikishore, Amaravadhi, Pethe, Kevin, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences::Biophysics; Science::Biological sciences::Biochemistry; Cytochrome bcc:aa3 Oxidase; Bioenergetics; OXPHOS; Tuberculosis; Mycobacterium Tuberculosis; Inhibitor
• Online Access: https://hdl.handle.net/10356/169212
• Institution: Nanyang Technological University

The mycobacterial cytochrome bcc:aa3 complex deserves the name “super-complex” since it combines three cytochrome oxidases—cytochrome bc,cytochromec, and cytochrome aa3—into one supramolecular machine and performs electron transfer for the reduction of oxygen to water and proton transport to gener...