Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI
The mycobacterial cytochrome bcc:aa3 complex deserves the name “super-complex” since it combines three cytochrome oxidases—cytochrome bc,cytochromec, and cytochrome aa3—into one supramolecular machine and performs electron transfer for the reduction of oxygen to water and proton transport to gener...
Saved in:
Main Authors: | Mathiyazakan, Vikneswaran, Wong, Chui Fann, Harikishore, Amaravadhi, Pethe, Kevin, Grüber, Gerhard |
---|---|
Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2023
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/169212 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
The Mycobacterium tuberculosis cytochrome bcc:aa3 cryo-EM structure and discovery of novel putative cytochrome bcc:aa3 inhibitors
by: Mathiyazakan, Vikneswaran
Published: (2023) -
Telacebec : an investigational antibacterial for the treatment of tuberculosis (TB)
by: Lee, Bei Shi, et al.
Published: (2022) -
Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery
by: Harikishore, Amaravadhi, et al.
Published: (2023) -
Antituberculosis activity of the antimalaria cytochrome bcc oxidase inhibitor SCR0911
by: Chong, Sherilyn Shi Min, et al.
Published: (2020) -
Structural elements involved in ATP hydrolysis inhibition and ATP synthesis of tuberculosis and non-tuberculous mycobacterial F-ATP synthase decipher new targets for inhibitors
by: Wong, Chui Fann, et al.
Published: (2022)