Polygenic risk scores for complex diseases: where are we now?

• Main Authors: Loh, Marie, Chambers, John Campbell
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Polygenic Risk Scores; Complex Diseases
• Online Access: https://hdl.handle.net/10356/169414
• Institution: Nanyang Technological University

Polygenic risk scores (PRS), commonly referred to as genetic or genomic risk scores, aggregate the effects of multiple genetic variants into a single composite estimate of genetic risk. PRS scores are typically used to predict the risk of developing a disease or to explain the phenotypic variation,...