Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice

• Main Authors: Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Beta Arrestin 2; Knockout Mouse
• Online Access: https://hdl.handle.net/10356/169850
• Institution: Nanyang Technological University

The glucagon-like peptide-1 receptor (GLP-1R) is a major type 2 diabetes therapeutic target. Stimulated GLP-1Rs are rapidly desensitized by β-arrestins, scaffolding proteins that not only terminate G protein interactions but also act as independent signaling mediators. Here, we have assessed in vivo...