Polarization of tumor-associated macrophages promoted by vitamin C-loaded liposomes for cancer immunotherapy

• Main Authors: Ma, Zhaoyu, Yang, Mingkun, Foda, Mohamed Frahat, Zhang, Kai, Li, Shuting, Liang, Huageng, Zhao, Yanli, Han, Heyou
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Checkpoint Blockade Immunotherapy; Macrophage Polarization
• Online Access: https://hdl.handle.net/10356/170510
• Institution: Nanyang Technological University

While checkpoint blockade immunotherapy as a promising clinical modality has revolutionized cancer treatment, it is of benefit to only a subset of patients because of the tumor immunosuppressive microenvironment. Herein, we report that the specified delivery of vitamin C at the tumor site by respons...