Catalytic regioselective acylation of unprotected nucleosides for quick access to COVID and other nucleoside prodrugs

• Main Authors: Lv, Jie, Zou, Juan, Nong, Yingling, Song, Jia, Shen, Tingwei, Cai, Hui, Mou, Chengli, Lyu, Wenxin, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Pentose Functionalization; Regioselective
• Online Access: https://hdl.handle.net/10356/171236
• Institution: Nanyang Technological University

Nucleosides have important therapeutic applications that include antiviral activities against COVID viruses. It is a common strategy to convert one or multiple of the hydroxyl (OH) units in nucleosides to the corresponding ester groups to prepare nucleoside prodrugs for better performance. Due to th...