Catalytic regioselective acylation of unprotected nucleosides for quick access to COVID and other nucleoside prodrugs

Nucleosides have important therapeutic applications that include antiviral activities against COVID viruses. It is a common strategy to convert one or multiple of the hydroxyl (OH) units in nucleosides to the corresponding ester groups to prepare nucleoside prodrugs for better performance. Due to th...

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Bibliographic Details
Main Authors: Lv, Jie, Zou, Juan, Nong, Yingling, Song, Jia, Shen, Tingwei, Cai, Hui, Mou, Chengli, Lyu, Wenxin, Jin, Zhichao, Chi, Robin Yonggui
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/171236
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Institution: Nanyang Technological University
Language: English

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