KOPI: kinase inhibitor proteome impact analysis

• Main Authors: Li, Ginny Xiaohe, Zhao, Tianyun, Wang, Loo Chien, Choi, Hyungwon, Lim, Yan Ting, Sobota, Radoslaw M.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Antineoplastic Agents; Phosphorylation
• Online Access: https://hdl.handle.net/10356/171280
• Institution: Nanyang Technological University

Kinase inhibitors often exert on/off-target effects, and efficient data analysis is essential for assessing these effects on the proteome. We developed a workflow for rapidly performing such a proteomic assessment, termed as kinase inhibitor proteome impact analysis (KOPI). We demonstrate KOPI'...