An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

• Main Authors: Lee, Wei Lin, Sinha, Ameya, Lam, Ling Ning, Loo, Hooi Linn, Liang, Jiaqi, Ho, Peiying, Cui, Liang, Chan, Cheryl Siew Choo, Begley, Thomas, Kline, Kimberly Ann, Dedon, Peter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Bactericidal Activity; Enterococcus Faecalis
• Online Access: https://hdl.handle.net/10356/171547
• Institution: Nanyang Technological University

Bacteria possess elaborate systems to manage reactive oxygen and nitrogen species (ROS) arising from exposure to the mammalian immune system and environmental stresses. Here we report the discovery of an ROS-sensing RNA-modifying enzyme that regulates translation of stress-response proteins in the g...