A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria

• Main Authors: Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen
• 其他作者: School of Chemistry, Chemical Engineering and Biotechnology
• 格式: Article
• 語言: English
• 出版: 2024
• 主題: Chemistry; Antibiotic agent; Drug resistance
• 在線閱讀: https://hdl.handle.net/10356/174218
• 機構: Nanyang Technological University

The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. We previously reported that polyimidazolium (PIM) compounds exhibited signi...