Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation

• Main Authors: Versi, Ali, Ivan, Fransiskus Xaverius, Abdel-Aziz, Mahmoud I., Bates, Stewart, Riley, John, Baribaud, Frederic, Kermani, Nazanin Zounemat, Montuschi, Paolo, Dahlen, Sven-Erik, Djukanovic, Ratko, Sterk, Peter, Maitland-Van Der Zee, Anke H., Chotirmall, Sanjay Haresh, Howarth, Peter, Adcock, Ian M., Chung, Kian Fan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Haemophilus influenzae; Moraxella catarrhalis
• Online Access: https://hdl.handle.net/10356/174355
• Institution: Nanyang Technological University

Background: Because of altered airway microbiome in asthma, we analysed the bacterial species in sputum of patients with severe asthma. Methods: Whole genome sequencing was performed on induced sputum from non-smoking (SAn) and current or ex-smoker (SAs/ex) severe asthma patients, mild/moderate asth...