Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transc...

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Bibliographic Details
Main Authors: Ghiasi, Seyed M., Marchetti, Piero, Piemonti, Lorenzo, Nielsen, Jens H., Porse, Bo T., Mandrup-Poulsen, Thomas, Rutter, Guy A.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Insulin secretion
Nonsense-mediated decay
Online Access:https://hdl.handle.net/10356/179681
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Institution: Nanyang Technological University
Language: English
Description
Summary:Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transcript isoforms targeted in ß cells.

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