Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

• Main Authors: Ghiasi, Seyed M., Marchetti, Piero, Piemonti, Lorenzo, Nielsen, Jens H., Porse, Bo T., Mandrup-Poulsen, Thomas, Rutter, Guy A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Insulin secretion; Nonsense-mediated decay
• Online Access: https://hdl.handle.net/10356/179681
• Institution: Nanyang Technological University

Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transc...