Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells
Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transc...
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sg-ntu-dr.10356-1796812024-08-18T15:39:47Z Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells Ghiasi, Seyed M. Marchetti, Piero Piemonti, Lorenzo Nielsen, Jens H. Porse, Bo T. Mandrup-Poulsen, Thomas Rutter, Guy A. Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Insulin secretion Nonsense-mediated decay Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transcript isoforms targeted in ß cells. Published version The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants to SG from the Medical Council for Independent Research Fund Denmark (Independent Postdoctoral International Mobility, grant number: 9034-00001B) and the Society for Endocrinology (SfE) (SEF/2021/ICL-SMG), London, UK. GR was supported by a Wellcome Trust Investigator (WT212625/Z/18/Z) Award, an MRC (UKRI) Programme grant (MR/R022259/1), an NIH-NIDDK project grant (R01DK135268), a CIHR-JDRF Team grant (CIHR-IRSC TDP-186358 and JDRF 4- SRA-2023-1182-S-N), CRCHUM start-up funds, and an Innovation Canada John R. Evans Leader Award (CFI 42649). This project has received funding from the European Union’s Horizon 2020 research and innovation program via the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 115881 (RHAPSODY) to GR and PM. Provision of human islets from Milan was supported by JDRF award 31-2008- 416 (ECIT Islet for Basic Research program). 2024-08-16T02:37:55Z 2024-08-16T02:37:55Z 2024 Journal Article Ghiasi, S. M., Marchetti, P., Piemonti, L., Nielsen, J. H., Porse, B. T., Mandrup-Poulsen, T. & Rutter, G. A. (2024). Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells. Frontiers in Endocrinology, 15, 1359147-. https://dx.doi.org/10.3389/fendo.2024.1359147 1664-2392 https://hdl.handle.net/10356/179681 10.3389/fendo.2024.1359147 38586449 2-s2.0-85189290291 15 1359147 en Frontiers in Endocrinology © 2024 Ghiasi, Marchetti, Piemonti, Nielsen, Porse, Mandrup-Poulsen and Rutter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
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Medicine, Health and Life Sciences Insulin secretion Nonsense-mediated decay |
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Medicine, Health and Life Sciences Insulin secretion Nonsense-mediated decay Ghiasi, Seyed M. Marchetti, Piero Piemonti, Lorenzo Nielsen, Jens H. Porse, Bo T. Mandrup-Poulsen, Thomas Rutter, Guy A. Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells |
| description |
Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transcript isoforms targeted in ß cells. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Ghiasi, Seyed M. Marchetti, Piero Piemonti, Lorenzo Nielsen, Jens H. Porse, Bo T. Mandrup-Poulsen, Thomas Rutter, Guy A. |
| format |
Article |
| author |
Ghiasi, Seyed M. Marchetti, Piero Piemonti, Lorenzo Nielsen, Jens H. Porse, Bo T. Mandrup-Poulsen, Thomas Rutter, Guy A. |
| author_sort |
Ghiasi, Seyed M. |
| title |
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells |
| title_short |
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells |
| title_full |
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells |
| title_fullStr |
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells |
| title_full_unstemmed |
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells |
| title_sort |
proinflammatory cytokines suppress nonsense-mediated rna decay to impair regulated transcript isoform processing in pancreatic β cells |
| publishDate |
2024 |
| url |
https://hdl.handle.net/10356/179681 |
| _version_ |
1814047293464117248 |