Zinc(ii)-mediated stereoselective construction of 1,2-cis 2-azido-2-deoxy glycosidic linkage: assembly of Acinetobacter baumannii K48 capsular pentasaccharide derivative

• Main Authors: Zhao, Xiaoya, Ding, Han, Guo, Aoxin, Zhong, Xuemei, Zhou, Siai, Wang, Guoqing, Liu, Yuhua, Ishiwata, Akihiro, Tanaka, Katsunori, Cai, Hui, Liu, Xue-Wei, Ding, Feiqing
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Capsular polysaccharide; Vaccine development
• Online Access: https://hdl.handle.net/10356/180583
• Institution: Nanyang Technological University

The capsular polysaccharide (CPS) is a major virulence factor of the pathogenic Acinetobacter baumannii and a promising target for vaccine development. However, the synthesis of the 1,2-cis-2-amino-2-deoxyglycoside core of CPS remains challenging to date. Here we develop a highly α-selective ZnI2-me...