Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

• Main Authors: Nayak, Sourav, Peto, Thomas J., Kucharski, Michal, Tripura, Rupam, Callery, James J., Duong, Tien Quang Huy, Gendrot, Mathieu, Lek, Dysoley, Ho, Dang Trung Nghia, van der Pluijm, Rob W., Nguyen, Dong, Le, Thanh Long, Vongpromek, Ranitha, Rekol, Huy, Nguyen, Hoang Chau, Miotto, Olivo, Mukaka, Mavuto, Dhorda, Mehul, von Seidlein, Lorenz, Imwong, Mallika, Roca, Xavier, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Bozdech, Zbynek
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Artemisinin; Antimalarial agent
• Online Access: https://hdl.handle.net/10356/182046
• Institution: Nanyang Technological University

The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other geneti...