The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

• Main Authors: Vind, Anna Constance, Wu, Zhenzhen, Muhammad Jasrie Firdaus, Snieckute, Goda, Toh, Gee Ann, Jessen, Malin, Martínez, José Francisco, Haahr, Peter, Andersen, Thomas Levin, Blasius, Melanie, Koh, Li Fang, Maartensson, Nina Loeth, Common, John E. A., Gyrd-Hansen, Mads, Zhong, Franklin, Bekker-Jensen, Simon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Pyroptosis; Ribotoxic stress response
• Online Access: https://hdl.handle.net/10356/182270
• Institution: Nanyang Technological University

Solar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cell death, and epidermal thickening, all of which have traditionally been associated with DNA damage response signaling. Another stress response that is...