TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

• Main Authors: Lascaux, Pauline, Hoslett, Gwendoline, Tribble, Sara, Trugenberger, Camilla, Antičević, Ivan, Otten, Cecile, Torrecilla, Ignacio, Koukouravas, Stelios, Zhao, Yichen, Yang, Hongbin, Aljarbou, Ftoon, Ruggiano, Annamaria, Song, Wei, Peron, Cristiano, Deangeli, Giulio, Domingo, Enric, Bancroft, James, Carrique, Loïc, Johnson, Errin, Vendrell, Iolanda, Fischer, Roman, Ng, Alvin Wei Tian, Ngeow, Joanne, D'Angiolella, Vincenzo, Raimundo, Nuno, Maughan, Tim, Popović, Marta, Milošević, Ira, Ramadan, Kristijan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Colorectal cancer; DNA repair
• Online Access: https://hdl.handle.net/10356/182452
• Institution: Nanyang Technological University

DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of DNA lesions. We discovered that lysosomes process topoisomerase 1 cleavage complexes (TOP1cc) DNA lesions i...