Structural and mutagenesis studies of the NS3 helicase from dengue virus for drug discovery

• Main Author: Yang, Xiaoqing
• Other Authors: Julien Lescar
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: http://hdl.handle.net/10356/18935
• Institution: Nanyang Technological University

With reference to the structure analysis of RNA unwinding mechanism coupled with ATP hydrolysis by Dengue virus (DEN) non-structural 3 (NS3) protein (Luo et al., 2008a), site-directed mutagenesis on DEN NS3 helicase domain was performed. Five residues conserved among Flaviviridae were selected for m...