Synthetic route to quinolines via microwave irradiation assisted triflic acid-catalyzed friedländer annulation.

• المؤلف الرئيسي: Hoeng, Murni.
• مؤلفون آخرون: Philip Wai Hong Chan
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2010
• الموضوعات: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/39834
• المؤسسة: Nanyang Technological University

An efficient triflic acid-catalyzed Friedländer annulation of 2-aminobenzophenone and ketone to afford quinolines under microwave irradiation is reported herein. The methodology gives a variety of quinolines with moderate to high yields (30-90%), achieved with 5 mol% of the Brønsted acid.