Towards the total synthesis of apicularen A
This thesis involves the synthesis of an intermediate towards Apicularen A utilizing indium-mediated conjugate addition of a thioester derived ketene to a conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential for its bioactivity as a potential anti-cancer agent.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/41762 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | This thesis involves the synthesis of an intermediate towards Apicularen A
utilizing indium-mediated conjugate addition of a thioester derived ketene to a
conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential
for its bioactivity as a potential anti-cancer agent. |
|---|