Towards the total synthesis of apicularen A

This thesis involves the synthesis of an intermediate towards Apicularen A utilizing indium-mediated conjugate addition of a thioester derived ketene to a conjugated ketone. This yields the important trans-2,6-hydroxypyran ring essential for its bioactivity as a potential anti-cancer agent.

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Bibliographic Details
Main Author: Chan, Jocelyn Li Ting
Other Authors: Loh Teck Peng
Format: Theses and Dissertations
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/41762
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Institution: Nanyang Technological University
Language: English

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